Hi, I've worked for a long time with Digital potentiometers for designing custom gain instrumentation amplifiers/signal subtractors.
The main issue is the wide range of resistance variation among chips while the laser-trimmered R values inside the single device is amazing.
This make a DIGIPOT useful for creating analog Resistor nets for operational amplifiers with low % differences inside the chip.
Another problem, I rembember, was the difference with real potentiomenters about bipolar signals in relationship with the power supply of the DIGIPOT. Some devices are exclusively for single supply applications while others for dual supply.
Just for having an idea and if you have time, read the following introductive document from Analg Devices:
https://www.analog.com/media/en/news-marketing-collateral/product-selection-guide/Choosing_the_Correct_Digipot.pdf